Peran Phosphatase Regenerating Liver-3 dan Vascular Endothelial Growth Factor dalam Progresivitas Kanker Ovarium Epitelial
نویسندگان
چکیده
Tujuan: Mengetahui peran phosphatase regenerating liver-3 (PRL-3) dan vascular endothelial growth factor (VEGF) dalam progresivitas kanker ovarium. Metode: Penelitian dilakukan pada penderita ovarium di beberapa rumah sakit jejaring Fakultas Kedokteran Universitas Hasanuddin Makassar. Pengambilan sampel dilaksanakan secara consecutive sampling. cairan ascites jaringan tumor saat operasi untuk pemeriksaan hematoksilin eosin immunohistokimia, mRNA dengan RT-PCR. Pemeriksaan mengukur histopatologi. imunohistokimia mengetahui ekskpresi PRL-3 VEGF. RT-PCR digunakan melakukan pemeriksaaan PRL-3. Data dianalisis uji chi-square analisis korelasi Spearman taraf signifikansi 5%. Hasil: Hasil diperoleh 38 subyek penelitian yang terdiri dari 26,3% stadium awal 73,7% lanjut. Ekspresi tidak berbeda bermakna berdasarkan stadium, derajat diferensiasi, lokasi p > 0,05. primer disertai metastasis lebih tinggi dibandingkan tanpa (p<0,05). VEGF primer, Ada positif antara ekspresi epitelial Kesimpulan: Tingginya meningkatkan epitelial.
منابع مشابه
Vascular Endothelial Growth Factor Production is Regulated by Gene Polymorphisms
Background: Vascular endothelial growth factor (VEGF) has a key role in angiogene-sis and in transplantation. The level of VEGF is related to the differences in the DNA sequence of its promoter region. Objectives: In this study, the association between the combination of VEGF –1154 G and –2578 C alleles and VEGF production by LPS-stimulated PBMCs was investigated. In addition; the relationship ...
متن کاملVascular Endothelial Growth Factor from Embryonic Status to Cardiovascular Pathology
Vascular endothelial growth factor (VEGF) is a multifunctional cytokine with distinct functions in angiogenesis, lymphangiogenesis, vascular permeability, and hematopoiesis. VEGF is a highly conserved, disulfide-bonded dimeric glycoprotein of 34 to 45 kDa produced by several cell types including fibroblasts, neutrophils, endothelial cells, and peripheral blood mononuclear cells, particularly T ...
متن کاملMesenchymal Stem Cells Differentiate to Endothelial Cells Using Recombinant Vascular Endothelial Growth Factor –A
Background: Vascular endothelial growth factor-A (VEGF-A), an endothelial cell-specific mitogen produced by various cell types, plays important roles in cell differentiation and proliferation. In this study we investigated the effect of recombinant VEGF-A on differentiation of mesenchymal stem cells (MSCs) to endothelial cells (ECs). Methods: VEGF-A was expressed in E. coli BL21 (DE3) and BL21...
متن کاملPlasma levels of vascular endothelial growth factor and its soluble receptor in non-alcoholic fatty liver disease
Introduction: Non-alcoholic fatty liver disease (NAFLD) is a clinical pathologic condition, which leads to inflammation events in hepatocytes. The objective of present study was to compare the plasma levels of VEGF and sVEGFR-1 as inflammation factors in overweight and obese children and adolescents with and without NAFLD. Materials and Methods: A total sample of 70 overweight and obese childre...
متن کاملRegulatory mechanisms of phosphatase of regenerating liver (PRL)-3
The phosphatase of regenerating liver (PRL)-3 is overexpressed in many human cancer types and tumor metastases when compared with healthy tissues. Different pathways and mechanisms have been suggested to modulate PRL-3 expression levels and activity, giving some valuable insights but still leaving an incomplete picture. Investigating these mechanisms could provide new targets for therapeutic dr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Obgynia
سال: 2023
ISSN: ['2615-496X']
DOI: https://doi.org/10.24198/obgynia/v6.n2.526